IMMUNE RESTORATION IN IMMUNOSUPPRESSION

(A hope for people living with HIV/AIDS, Poor/damaged immune system)

 (By David Oluwa, Laboratory analyst, Microbiologist/Virologist)

PACMAI INT’L LTD, LAGOS

WHAT IS IMMUNITY?

Immunity may be defined as the ability or power of the body to resist infection by microorganisms or the harmful effects of their toxins.

The process by which immunity (natural or acquired, active or passive) is conferred on an individual is called immunization. The body’s natural ability to protect itself from the onslaught of offending virus, bacteria, fungi, etc, can be enhanced or weakened by a number of factors:

 
We each have experienced that sudden attack of cold that sets in after an extra ordinary stressful cycle such as many days of celebration or of more serious events such as the death of loved ones, divorce, loss of a job, stressful journey etc. All such events can weaken our immune system and make us susceptible to various intractable diseases like malaria, cancer, hepatitis, tuberculosis, HIV/Aids, etc.

Poor diet, inadequate nutrition, continual stress, negative emotions, environmental poisons, abuse of drugs, excessive alcoholism and smoking, lack of exercise can all contribute to the inability of our immune system to properly defend or protects us.

Herbal support of immune activities is an example where Herbal medicine is being confirmed by modern pharmaceuticals research, with many remedies showing complimentary immunological effect in both laboratory and clinical trials.(This is where HITPAC Granules takes the lead). Because they support natural responses to be more flexible in the face of disease these herbs are described as immune-modulators. These herbs provide a potential alternative to conventional chemotherapy of infection especially with people having an impaired immune response. As these herbs support the body’s own immune mechanism there is also the possibility of preventing opportunistic infections.

In case of tuberculosis, hepatitis, HIV/Aids etc. it has been shown that the natural defense mechanism of the individual sufferer can be augmented with herbal therapy, not only to destroy the causative agent but also to prevent opportunistic infections. This is where HITPAC Granules is the Oga or Lord of all and takes the lead.

VIRAL INFECTIONS:

The majority of virus infections resolve spontaneously in immunocompetent persons. A number of specific treatments for viral infections are available particularly for the immunocompromised persons but HITPAC GRANULES should be the first choice and the best.

Immunocomprised persons are those whose immune system is weak for other reasons, (such as for e.g. chemotherapy, Herpes simplex, lupus, HIV, Varicella-zoster, cytomegalovirus, influenza, viral hepatitis, and respiratory syncytial virus.)

INTRODUCING HITPAC GRANULES: ------------ 

Hitpac Granules is an multi-herbal product developed in recognition that although modern drugs do help immune suppressed subjects regain good health, their many side effects calls for the need for other safer options. It is beneficial to people with low immunity by stimulating increased immunity and restraining viral replication without any harmful side effects.

COMPOSITION OF HITPAC GRANULES:

Consist of well-known natural plants and has no any addictives. All ingredients contained are in line with the requirement of ministry of health of Hong Kong government on crude materials for medicine and food. It is a scientifically developed product combining ancient classic prescription with modern pharmaceutical research. The production process is strictly in accordance with GMP.

Each 15g sachet contains: 23.33% Aloe ferox Miller, 16.67% Ginkgo biloba L., 16.68% Citrus reticulate Blanco, 13.33% Salvia miltiorrhiza Bge., 13.33% Lonicera japonica Thunb., 13.33% Houttuynia cordata Thunb., 3.33% Cordyceps

MODE OF ACTION:

The product works by stimulating the immune system by which the lymphocyte function is enhanced. The enhancement of the self-recovery capability of human body through the activation of the dormant T-cells ensures that the viral replication is kept on check by normal body defense systems. The inactive viruses are not allowed to mutate and as a result resistance possibility is reduced. The ultimate goal would be to suppress viral load increase which ultimately increase the burden to the immune system hence its restoration and maintenance. The restored immunity is key in the protection against opportunistic infections. The improved and restored human lymphocyte transformation, inhibit virus duplication, promote the recovery of immune function effectively and improve the quality of life but with minimal or no side effects that define the commonly used anti HIV drugs.

BENEFITS:

Hitpac Granules is a high-tech special multi-herbal product for immune restoration in immunosuppressive ailments and people in poor health. It restores and improves the quality of life and vigor, endurance and strength.

In both laboratory and clinical trials, Hitpac Granules shows complementary immunological effect on the immune system and provoke productive immune responses in infected individuals.

Hitpac Granules: has beneficial clinical effect on HIV & AIDS patients as it stimulates their appetite, improve their vital signs and stalled disease progression without causing any notable adverse effect. Notably subjects on Hitpac Granules reported reductions in respiratory infections, unexplained fevers, headache, skin rashes, diarrhea, cough, fatigue and remarkable increase in appetite.

Hitpac Granules: stimulates immunity through increase lymphocyte, CD3, CD4 and white blood cells proliferation; all of which are necessary for enhanced viral defense hence is effective in viral load reduction.

Hitpac granules: is effective in viral load reduction as evidenced by a large proportion of subjects who reduced their viral load to undetectable levels by the 22^nd month of intervention, as well as the absolute reduction in viral load. Among subjects on Hitpac those with undetectable viral load at the 22^nd month of intervention were 45% of the total subjects.

There are no side effects experienced to date, on the contrary it enhance the function of liver and kidney and reduce the complications.

Other benefits:

*Improving the body immunity and prevention against infections to normal people.

*Injured tissues and organs have to be quickly restored, which bring the obvious improvements of clinical manifestation such as better spirit, stronger physical strength, weight increase and general well being which is good in recovering patients. 

INDICATION:

It is indicated for patients whose immune systems have weakened to boost the immune system.

DIRECTION FOR USE:

*Adults 1 sachet (15g) in a glass of hot water thrice a day

*Children (6 – 12years) ½ sachet (15g) in a glass of hot water thrice a day

PRECAUTIONS:

·       Avoid alcohol, spicy food, banana, sea-foods and fructus foeniculi, during the management period

·       Take it at recommended time

·       It’s advised to take three consecutive periods of treatment or more in order to get better effects (one period of treatment covers three months)

·       Keep out of reach of children

ADVICE

An HIV+ person should do everything in his or her power to keep the immune system as healthy for as long as possible (in other words, to keep the viral load as low and the CD4 cell count as high as possible.) this can be done through the following but not limited to,

·       A healthy life style (rest, exercise)

·       Stress management and positive living

·       A healthy, balanced diet

·       Supplements and immune-boosters

·       Avoidance of the use recreational drugs, alcohol abuse and smoking

·       Routine visits to the doctor or clinic – early treatment of opportunistic infections

·       Antiviral therapy

FAQS:

What is the “viral load” and how is it measured?

·       The viral load refers to the actual number of viruses in the blood. The viral load can be “counted” by doing blood tests. The virus count is indicated in copies per ml. viral load is an indication of how sick an HIV infected person is (prognosis), and it is also used to measure a person’s response to antiretroviral treatment.

What is the CD4 cell count?

·         The CD4 lymphocyte count is an excellent indicator of how healthy the immune system is. The CD4 cell count is indicated in cell per mm³, and it is measure by taking a blood sample.

·        Although the normal number of CD4 cells varies from individual to individual, it is usually between 500 and 1500.

·        CD4 cell counts are the best predicators of the risk of opportunistic diseases.

·        CD4 values below 500 cells per mm³ are usually an indication of immune suppression and vulnerability to opportunistic infections. (For example, preventative treatment for tuberculosis should start when a patient’s CD4 cell count drops below 350 cells per mm³.)

·        Clinical over view: quantization of CD4 cells in peripheral blood is an essential tool for laboratory monitoring of HIV infected patients. CD4+ T-lymphocytes (otherwise called helper T-cells) are the coordinators of immune response i.e body defense mechanism against micro-organism and some forms of cancer. These cells (CD4+ T-lymphocytes) constitute the primary targets of the Human Immunodeficiency Virus (HIV).

·        Note that the destruction of CD4 cells is the main cause of progressive weakening of the immune system in HIV infection, which ultimately lead to Acquired Immune Deficiency Syndrome (AIDS). Lower number of circulating CD4 T-cells imply a more advanced stage of HIV disease and translate to less competent defense mechanism.        

What is the relationship between viral load, CD4 count and diseases progression?

·        There is a very special relationship between the viral load and the CD4 cell count, and if considered together, they can predict whether a person’s journey towards Aids (the final stage of disease) will be rapid or slow.

·        Viral load and CD4 cells vary together which means that the higher viral load will lead to a lower CD4 counts (because the virus destroys the CD4 cells), while the lower viral load will go hand in hand with a higher CD4 cell count (because less viruses in the blood give the immune system a chance to build up it resources again.)

·        Disease progression (the extend to which an HIV positive person get sick with opportunistic diseases and infections) will depend on the viral load as well as the CD4 cell count in the blood. The higher the viral load, and the lower the CD4 cell count, the easier it will be for all kinds of infections to attack the body. The progression to the final phase of AIDS (and death) will therefore be much faster with a high viral load.

On the other hand, an HIV-infected person with a low viral load and a high CD4 count can stay healthy for many years, because the immune system is strong enough to fight off infections.   

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